Methylenedioxyhydroxyamphetamine

Methylenedioxyhydroxyamphetamine (MDOH) is a lesser-known psychedelic drug and a substituted amphetamine. MDOH was first synthesized by Alexander Shulgin. In his book PiHKAL (Phenethylamines I Have Known and Loved), the dosage range is listed as 100-160 mg, and the duration is listed as 3–6 hours. Shulgin describes MDOH as a promoter of empathy.

Chemistry

Methylenedioxyhydroxyamphetamine, or MDOH, is a member of the substituted amphetamine class of compounds, specifically a substituted methylenedioxyphenethylamine. It is structurally similar to MDMA, differing by the addition of a single hydroxy group.

Pharmacology

The pharmacological mechanisms of MDOH are not well known. However, it is likely that it acts as a serotonin releasing agent (SRA), similar to its better-known relative MDMA. This would result in increased levels of serotonin in the brain, which could contribute to its reported empathogenic effects.

Effects

The effects of MDOH are not well documented, but reports suggest that it produces a mixture of entactogenic and psychedelic effects. These may include feelings of empathy, euphoria, and altered perception. However, the potential for negative effects such as anxiety, paranoia, and neurotoxicity should not be overlooked.

Legality

MDOH is not specifically listed as a controlled substance in most countries, but its structural similarity to controlled substances such as MDMA could potentially subject it to laws against analogue drugs.

See also

• Substituted amphetamine
• Substituted methylenedioxyphenethylamine
• Psychedelic drug
• Alexander Shulgin
• PiHKAL