Isosafrole

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Isosafrole


Isosafrole is an organic compound with the formula C10H10O2. It is a colorless or slightly yellow oily liquid with a characteristic smell and is one of the key components in the synthesis of the psychedelic drug MDMA (commonly known as ecstasy). Isosafrole is found naturally in small quantities in various essential oils, most notably in sassafras oil, from which it was historically derived. However, due to its use in the illicit manufacture of MDMA, the production and sale of isosafrole are regulated in many countries.

Properties[edit | edit source]

Isosafrole is an isomer of safrole, another compound found in sassafras oil. It has a boiling point of 253°C and a density of 1.122 g/cm³. Isosafrole is slightly soluble in water but mixes well with most organic solvents.

Synthesis[edit | edit source]

Isosafrole can be synthesized from safrole through isomerization, which can be achieved using a strong base or by heating. In the industrial synthesis of MDMA, isosafrole is often oxidized to piperonal, which then undergoes several more steps to produce the final product.

Regulation[edit | edit source]

Due to its association with the synthesis of MDMA, isosafrole is listed as a List I chemical under the United States Controlled Substances Act, meaning that sales and imports are tightly controlled. Similar regulations exist in other countries to prevent its misuse.

Uses[edit | edit source]

Historically, isosafrole was used in the manufacture of fragrances and as a flavoring agent due to its pleasant aroma. However, its use in the food and cosmetic industry has significantly declined due to health concerns and regulatory restrictions. Today, its legitimate use is primarily limited to research and industrial applications not related to drug synthesis.

Health Effects[edit | edit source]

Isosafrole has been shown to have hepatotoxic and carcinogenic effects in animal studies. The International Agency for Research on Cancer (IARC) has classified isosafrole as a Group 2B carcinogen, indicating it is possibly carcinogenic to humans. Exposure to isosafrole should be minimized, and safety precautions should be taken when handling it.

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Contributors: Prab R. Tumpati, MD