Guanazodine

Guanazodine is a pharmacological agent that belongs to the class of antihypertensive drugs. It is primarily used in the treatment of hypertension, a condition characterized by persistently elevated blood pressure.

Mechanism of Action

Guanazodine works by inhibiting the release of norepinephrine from the sympathetic nervous system's nerve endings. This results in a decrease in vasoconstriction and heart rate, thereby lowering blood pressure.

Pharmacokinetics

After oral administration, Guanazodine is absorbed from the gastrointestinal tract. It is metabolized in the liver and excreted in the urine.

Side Effects

Like other antihypertensive drugs, Guanazodine may cause side effects such as dizziness, headache, and fatigue. In some cases, it may also cause orthostatic hypotension, a form of low blood pressure that occurs when you stand up from sitting or lying down.

Contraindications

Guanazodine is contraindicated in patients with known hypersensitivity to the drug. It should also be used with caution in patients with severe renal impairment or hepatic impairment, as these conditions may affect the drug's metabolism and excretion.

Interactions

Guanazodine may interact with other medications, including other antihypertensive drugs, diuretics, and antidepressants. These interactions may increase the risk of side effects or alter the effectiveness of the drug.

See Also

• Antihypertensive drugs
• Hypertension
• Pharmacology
• Pharmacokinetics