3-Iodothyronamine

3-Iodothyronamine (T1AM) is a metabolite of thyroid hormone that is produced by decarboxylation of thyronamine. It is a trace amine and has been found to have profound effects on mammalian physiology, including lowering body temperature and decreasing insulin production.

Structure and Synthesis

3-Iodothyronamine is a derivative of thyronamine, which is itself a metabolite of thyroxine (T4), one of the two major hormones produced by the thyroid gland. The synthesis of 3-iodothyronamine involves the decarboxylation of thyronamine, a process that is thought to be mediated by aromatic L-amino acid decarboxylase (AADC).

Physiological Effects

The physiological effects of 3-iodothyronamine are diverse and significant. It has been found to cause a rapid drop in body temperature in mice, an effect that is thought to be mediated by activation of the trace amine-associated receptor 1 (TAAR1). In addition to its effects on body temperature, 3-iodothyronamine has also been found to decrease insulin production, suggesting a potential role in the regulation of glucose metabolism.

Potential Therapeutic Uses

Due to its effects on body temperature and insulin production, 3-iodothyronamine has been suggested as a potential therapeutic agent for conditions such as hypothermia and diabetes. However, further research is needed to fully understand the mechanisms of action of this compound and to assess its safety and efficacy in humans.

See Also

• Thyroid hormone
• Thyronamine
• Trace amine-associated receptor 1

References

3-Iodothyronamine Resources
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