Naltrexone/bupropion

Naltrexone/bupropion is a combination drug used for weight loss in those that are either obese or overweight with some weight-related illnesses. It combines low doses of bupropion and naltrexone. Both drugs have individually shown some evidence of effectiveness in weight loss, and the combination has been shown to have some synergistic effects on weight.

Mechanism of action[edit | edit source]

The exact neurochemical effects of Contrave leading to weight loss are not fully understood. However, it is known that bupropion is a reuptake inhibitor for both norepinephrine and dopamine, and naltrexone is a opioid receptor antagonist.

Side effects[edit | edit source]

The most common side effects observed with naltrexone/bupropion include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea. More serious side effects may include seizures, suicidal thoughts and behaviors, and severe allergic reactions.

Contraindications[edit | edit source]

Naltrexone/bupropion is contraindicated in individuals with uncontrolled high blood pressure, seizures, or with a history of anorexia nervosa or bulimia nervosa. It is also contraindicated in patients undergoing an abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.

Interactions[edit | edit source]

Naltrexone/bupropion has several potential drug interactions. It can interact with certain types of antidepressants, antipsychotics, beta-blockers, and certain types of opioids.

See also[edit | edit source]

Naltrexone/bupropion Resources
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