Carbonic anhydrase 13

Carbonic anhydrase 13 (CA13) is a type of enzyme that in humans is encoded by the CA13 gene. It is a member of the carbonic anhydrases family, which are enzymes that catalyze the rapid conversion of carbon dioxide and water into bicarbonate ions and protons. This reaction is fundamental to many processes in the body, including respiration and the transport of carbon dioxide in the blood.

Function

The primary function of carbonic anhydrase 13 is to assist in the rapid conversion of carbon dioxide and water into bicarbonate ions and protons. This is a crucial process in the body, as it helps to maintain acid-base balance in the blood and other tissues. It also plays a role in the formation of body fluids, bone resorption, and the secretion of gastric acid.

Structure

Like other carbonic anhydrases, CA13 is a protein that is made up of a single chain of amino acids. It has a molecular weight of approximately 29,000 daltons. The active site of the enzyme contains a zinc ion, which is crucial for its catalytic activity.

Clinical significance

Alterations in the CA13 gene have been associated with a variety of medical conditions. For example, mutations in this gene have been linked to renal tubular acidosis, a condition characterized by an inability of the kidneys to properly acidify the urine. Additionally, overexpression of CA13 has been observed in certain types of cancer, suggesting a potential role in tumor progression.

See also

• Carbonic anhydrase
• Gene
• Enzyme