Meta-Octopamine

Meta-Octopamine is a naturally occurring biogenic amine that is structurally related to norepinephrine. It is found in various animal species, including invertebrates and vertebrates, and plays a role in a variety of physiological processes.

Chemistry

Meta-Octopamine, also known as m-Octopamine, is a phenethylamine derivative with the chemical formula C8H11NO2. It is a positional isomer of octopamine, differing only in the position of the hydroxyl group on the benzene ring.

Biosynthesis

Meta-Octopamine is synthesized from tyramine through the action of the enzyme tyramine beta-hydroxylase. This enzyme catalyzes the addition of a hydroxyl group to the beta position of tyramine, resulting in the formation of meta-Octopamine.

Physiological Role

In many invertebrates, meta-Octopamine acts as a neurotransmitter or neuromodulator, influencing a variety of behaviors such as locomotion, feeding, and learning. In vertebrates, its role is less well understood, but it is thought to be involved in the regulation of metabolism and thermogenesis.

Pharmacology

Meta-Octopamine has been found to interact with a variety of receptor types, including adrenergic receptors and octopamine receptors. It has been shown to have both agonist and antagonist activity, depending on the receptor type and the species in which it is studied.

Research and Clinical Significance

Research into the role of meta-Octopamine in various physiological processes and diseases is ongoing. It has been implicated in a variety of conditions, including obesity, diabetes, and neurodegenerative diseases. However, much remains to be learned about its precise functions and potential therapeutic applications.

See Also

• Octopamine
• Tyramine
• Biogenic amine
• Neurotransmitter
• Neuromodulator