Norfenefrine

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Norfenefrine (also known as meta-octopamine, 3-octopamine, or 3,β-dihydroxyphenethylamine) is a cardiovascular drug used in certain countries. It is a norepinephrine analog where the 4-position hydroxyl group has been removed.

Pharmacology[edit | edit source]

Norfenefrine acts as a norepinephrine-releasing agent. It is a sympathomimetic amine that mimics the actions of the sympathetic nervous system, which includes the release of norepinephrine. Norfenefrine has been found to induce the release of norepinephrine from storage vesicles in the nerve endings into the synaptic cleft, where it acts on adrenergic receptors.

Medical Uses[edit | edit source]

Norfenefrine is used for the treatment of low blood pressure, especially orthostatic hypotension. It can also be used for the treatment of certain heart conditions, such as chronic heart failure.

Side Effects[edit | edit source]

Possible side effects of Norfenefrine include palpitations, tachycardia, arrhythmia, and hypertension. It may also cause anxiety, nervousness, and tremors.

Interactions[edit | edit source]

Norfenefrine may interact with other drugs, such as monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and other sympathomimetic amines.

See Also[edit | edit source]

References[edit | edit source]


Norfenefrine Resources
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