TAAR1

TAAR1 (Trace Amine-Associated Receptor 1) is a protein that in humans is encoded by the TAAR1 gene. TAAR1 is a high-affinity receptor for trace amines, a class of amines that are found in low levels in mammalian systems, but have significant physiological effects.

Function

TAAR1 is a G protein-coupled receptor (GPCR) that is expressed in the brain and peripheral tissues of humans and other mammals. It is thought to play a role in the regulation of neurotransmitter systems, including dopamine, serotonin, and norepinephrine. TAAR1 activation has been shown to reduce the activity of these neurotransmitter systems, suggesting a potential role in the treatment of psychiatric disorders such as schizophrenia, depression, and substance abuse.

Clinical significance

Several studies have suggested that TAAR1 may be a promising target for the treatment of a variety of psychiatric disorders. For example, TAAR1 agonists have been shown to have antipsychotic effects in animal models of schizophrenia, and to reduce drug-seeking behavior in models of addiction. In addition, TAAR1 antagonists have been shown to have antidepressant effects in animal models of depression.

See also

• Trace amine
• G protein-coupled receptor
• Neurotransmitter
• Schizophrenia
• Depression
• Substance abuse

External links

• TAAR1 at WikiMD

TAAR1 Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski