Sorivudine
(Redirected from Brovavir)
Sorivudine (INN) chemical name (E)-5-(2-Bromovinyl)- 1β-D-arabinofuranosyluracil, is a thymine analogue antiviral drug, marketed under trade names such as Usevir (Nippon Shoji, Eisai) and Brovavir (BMS).
Pharmacology[edit | edit source]
Feature[edit | edit source]
- First-line treatment of herpes drug acyclovir was (Zovirax, Activir) from VZV strong activity of the virus.
- Superior gastrointestinal absorption, absorption from the gastrointestinal tract after the most degrading without being excreted as urine.
Mechanism of action[edit | edit source]
- Sorivudine is phosphorylated by thymidine kinase activity in the body and is absorbed into the virus's DNA instead of the correct nucleoside. It is a competitive inhibitor of DNA polymerase, so the viral DNA cannot be replicated and the virus cannot grow.
Microbiology[edit | edit source]
Sorivudine is active against most species in the herpesvirus family.
- Herpes simplex virus type I (HSV-1)
- Varicella zoster virus (VZV)
- Epstein-Barr virus (EBV)
Resources[edit source]
Latest articles - Sorivudine
Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Sorivudine for any updates.
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