Sorivudine

Sorivudine (INN) chemical name (E)-5-(2-Bromovinyl)- 1β-D-arabinofuranosyluracil, is a thymine analogue antiviral drug, marketed under trade names such as Usevir (Nippon Shoji, Eisai) and Brovavir (BMS).

Pharmacology[edit | edit source]

Feature[edit | edit source]

First-line treatment of herpes drug acyclovir was (Zovirax, Activir) from VZV strong activity of the virus.
Superior gastrointestinal absorption, absorption from the gastrointestinal tract after the most degrading without being excreted as urine.

Mechanism of action[edit | edit source]

Sorivudine is phosphorylated by thymidine kinase activity in the body and is absorbed into the virus's DNA instead of the correct nucleoside. It is a competitive inhibitor of DNA polymerase, so the viral DNA cannot be replicated and the virus cannot grow.

Microbiology[edit | edit source]

Sorivudine is active against most species in the herpesvirus family.

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Resources[edit source]

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‎ Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Sorivudine for any updates.

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