Budesonide/glycopyrrolate/formoterol fumarate
Budesonide/glycopyrrolate/formoterol fumarate is a fixed-dose combination medication used in the management of COPD. It contains three active ingredients: Budesonide, a corticosteroid; Glycopyrrolate, an anticholinergic; and Formoterol fumarate, a long-acting beta-2 agonist.
Pharmacology[edit | edit source]
Budesonide is a glucocorticoid steroid that works by reducing inflammation in the lungs. It is absorbed into the cells of the lung tissues where it binds to the glucocorticoid receptor, leading to a variety of anti-inflammatory effects.
Glycopyrrolate is an anticholinergic agent that works by blocking the action of acetylcholine, a neurotransmitter that can cause bronchoconstriction. By blocking the action of acetylcholine, glycopyrrolate helps to relax and open the airways.
Formoterol fumarate is a long-acting beta-2 agonist (LABA) that works by stimulating beta-2 receptors in the lungs, which causes relaxation of bronchial smooth muscle, thus widening the airways and improving breathing.
Clinical Use[edit | edit source]
Budesonide/glycopyrrolate/formoterol fumarate is indicated for the maintenance treatment of patients with COPD. It is not indicated for the relief of acute bronchospasm or for the treatment of Asthma.
Side Effects[edit | edit source]
Common side effects of Budesonide/glycopyrrolate/formoterol fumarate include upper respiratory tract infection, pneumonia, bronchitis, oral candidiasis, and cough. Less common but more serious side effects can include worsening of COPD, irregular heartbeat, high blood pressure, and allergic reactions.
Contraindications[edit | edit source]
Budesonide/glycopyrrolate/formoterol fumarate is contraindicated in patients with a hypersensitivity to any of the active ingredients or to any of the excipients. It is also contraindicated in patients with asthma without use of a long-term asthma control medication.
See Also[edit | edit source]
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