CYP2J2

CYP2J2 is a gene in the human body that encodes a member of the cytochrome P450 superfamily of enzymes. These enzymes are a group of heme-thiolate monooxygenases, which are involved in the metabolism of a wide array of both endogenous and exogenous compounds.

Function

The Cytochrome P450 enzymes are responsible for the oxidation of organic substances. The CYP2J2 enzyme, in particular, is known to metabolize drugs such as astemizole, terfenadine, cyclosporine, and tacrolimus. In addition, it also metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs).

Clinical significance

Alterations in the CYP2J2 gene have been associated with various medical conditions. For instance, polymorphisms in this gene are associated with variations in the metabolism of certain drugs, which can affect the efficacy and toxicity of these medications.

Furthermore, research has suggested that the CYP2J2 gene may play a role in the development of cardiovascular diseases. The EETs produced by the CYP2J2 enzyme have vasodilatory and anti-inflammatory effects, which can protect against the development of hypertension and atherosclerosis.

See also

• Cytochrome P450
• Pharmacogenomics
• Cardiovascular disease

External links

• GeneCards - CYP2J2

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