Deslanoside

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(Redirected from Cedilanid-d)

Deslanoside is a cardiac glycoside used primarily in the treatment of congestive heart failure and atrial fibrillation. It is derived from the leaves of the Digitalis lanata plant, hence its name. Deslanoside acts by inhibiting the Na⁺/K⁺-ATPase pump, which leads to an increase in intracellular sodium. This increase in sodium concentration inside the cell triggers a secondary effect of increasing intracellular calcium levels by the sodium-calcium exchange pump, which enhances cardiac muscle contraction. This mechanism of action is crucial in improving the heart's efficiency and output, making deslanoside an important agent in managing specific heart conditions.

Pharmacokinetics[edit | edit source]

Deslanoside has a rapid onset of action when administered intravenously, with effects typically observed within 30 minutes. Its bioavailability varies when given orally, and it is extensively bound to plasma proteins. The drug is metabolized in the liver and excreted primarily in the urine. The half-life of deslanoside is relatively short, necessitating frequent dosing to maintain therapeutic levels in the bloodstream.

Clinical Uses[edit | edit source]

Deslanoside is used in the management of congestive heart failure (CHF), particularly in cases where the condition is refractory to other treatments. It is also employed in controlling the ventricular rate in patients with atrial fibrillation (AF). By improving the heart muscle's contractility, deslanoside helps to alleviate symptoms associated with CHF such as shortness of breath, fatigue, and edema.

Side Effects[edit | edit source]

The therapeutic window of deslanoside is narrow, making the risk of toxicity significant. Symptoms of deslanoside toxicity include nausea, vomiting, diarrhea, confusion, and vision disturbances such as seeing halos around lights. Cardiac side effects are particularly concerning and can include arrhythmias such as ventricular tachycardia or ventricular fibrillation. Monitoring of blood levels and careful dose adjustments are essential to minimize the risk of adverse effects.

Contraindications[edit | edit source]

Deslanoside is contraindicated in patients with ventricular fibrillation, hypokalemia (low potassium levels), and those with a known hypersensitivity to digitalis preparations. Caution is advised in patients with renal impairment, as reduced renal function can lead to accumulation of the drug and increase the risk of toxicity.

Interactions[edit | edit source]

Deslanoside can interact with a variety of medications, including diuretics, calcium channel blockers, and beta blockers. These interactions can either potentiate the effects of deslanoside, increasing the risk of toxicity, or reduce its efficacy. It is crucial to review all medications a patient is taking before initiating deslanoside therapy.

Conclusion[edit | edit source]

Deslanoside is a valuable drug in the management of certain heart conditions, particularly congestive heart failure and atrial fibrillation. Its use requires careful monitoring due to its narrow therapeutic window and potential for significant side effects. When used appropriately, deslanoside can significantly improve the quality of life for patients with heart failure and other cardiac conditions.


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