Amlodipine/valsartan

Amlodipine/valsartan is a medication combination used in the treatment of high blood pressure. It is a combination of two active ingredients: amlodipine, a calcium channel blocker, and valsartan, an angiotensin II receptor antagonist.

Indications

Amlodipine/valsartan is indicated for the treatment of hypertension to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.

Mechanism of Action

Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Valsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland.

Side Effects

Common side effects of amlodipine/valsartan include dizziness, swelling, flushing, and heart palpitations. Serious side effects may include kidney problems, low blood pressure, and high blood potassium.

Interactions

Amlodipine/valsartan may interact with other medications, including other blood pressure medications, heart medications, and diuretics. It is important to inform your healthcare provider of all medications you are currently taking.

Precautions

Before taking amlodipine/valsartan, tell your doctor if you have any history of heart disease, liver disease, or kidney disease. This medication should be used with caution in the elderly and those with impaired renal function.

Dosage

The dosage of amlodipine/valsartan is based on the patient's medical condition and response to treatment. It is typically taken once daily, with or without food.

See Also

• Calcium channel blocker
• Angiotensin II receptor antagonist
• Hypertension
• Cardiovascular disease

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