DOV-102677

DOV 102,677 is a triple reuptake inhibitor that inhibits the reuptake of serotonin, norepinephrine, and dopamine with IC50 values of 129 nM, 103 nM, and 133 nM, respectively. It is an analogue of tametraline.

Pharmacology

DOV 102,677 is a triple reuptake inhibitor, meaning it inhibits the reuptake of three neurotransmitters: serotonin, norepinephrine, and dopamine. This increases the amount of these neurotransmitters in the brain, which can help to alleviate symptoms of certain mental health conditions.

The IC50 values of DOV 102,677 for serotonin, norepinephrine, and dopamine are 129 nM, 103 nM, and 133 nM, respectively. The IC50 value is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. In this case, it refers to the concentration of DOV 102,677 needed to inhibit the reuptake of these neurotransmitters by 50%.

DOV 102,677 is an analogue of tametraline, a drug that was originally developed as an antidepressant but was never marketed.

Clinical significance

The ability of DOV 102,677 to inhibit the reuptake of serotonin, norepinephrine, and dopamine could make it a potential treatment for a variety of mental health conditions, including depression, anxiety disorders, and attention deficit hyperactivity disorder (ADHD). However, as of now, it is not approved for any use in any country.

See also

• DOV Pharmaceutical
• Triple reuptake inhibitor
• Tametraline

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