DRD2

DRD2 (Dopamine Receptor D2) is a protein that in humans is encoded by the DRD2 gene. This protein is one of five (D1-D5) dopamine receptors, and they are G protein-coupled receptors that are responsible for regulating numerous functions of the brain.

Function

The DRD2 is involved in a wide variety of behaviors, including locomotion, pleasure, and reward, as well as modulation of neuroendocrine secretion. Abnormalities in the function of this receptor have been implicated in numerous neuropsychiatric disorders. Antipsychotic drugs, including those used in the treatment of schizophrenia, act by blocking this receptor.

Gene

The DRD2 gene is located on chromosome 11 in humans. It is a member of the G protein-coupled receptor superfamily. This gene has been implicated in various neuropsychiatric disorders and its altered expression has been associated with schizophrenia and drug addiction.

Clinical significance

Alterations in the DRD2 gene have been associated with numerous disorders, including schizophrenia, bipolar disorder, and addiction. Antipsychotic drugs, which are used to treat schizophrenia and bipolar disorder, act by blocking the DRD2 receptor.

See also

• Dopamine receptor
• Dopamine
• G protein-coupled receptor
• Schizophrenia
• Bipolar disorder
• Addiction

References

DRD2 Resources
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