DTBZ
DTBZ or Dihydrotetrabenazine is a radioligand and VMAT2 inhibitor. It is used in medical imaging to map the distribution of VMAT2 in the brain, and as a research tool in drug discovery.
Chemistry[edit | edit source]
DTBZ is a derivative of tetrabenazine, a drug used to treat hyperkinetic movement disorders. It is synthesized by reducing tetrabenazine with sodium borohydride in an alcohol solution.
Medical uses[edit | edit source]
DTBZ is used in PET imaging to map the distribution of VMAT2 in the brain. This is useful in the study of Parkinson's disease and other neurodegenerative disorders, as VMAT2 is a marker for dopaminergic neurons, which are lost in these conditions.
Research uses[edit | edit source]
In addition to its use in imaging, DTBZ is also used as a research tool in drug discovery. It can be used to screen for new VMAT2 inhibitors, which could potentially be used to treat conditions such as schizophrenia, bipolar disorder, and depression.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
