Delta-8-tetrahydrocannabinol

From WikiMD's Wellness Encyclopedia

Delta-8-tetrahydrocannabinol (Delta-8-THC) is a psychoactive cannabinoid found in the Cannabis plant. It is an isomer of Delta-9-tetrahydrocannabinol (Delta-9-THC), the compound commonly known as THC. Delta-8-THC is less potent than its close relative but has been reported to have similar psychoactive effects.

Chemistry[edit | edit source]

Delta-8-THC, like other cannabinoids, is a part of the cannabis plant's natural chemical makeup. Chemically, it differs from Delta-9-THC by the position of a double bond in its molecular structure. This slight difference in chemical structure means that, while Delta-8-THC can bind to the cannabinoid receptors in the human body, it does so in a slightly different manner, which results in its lower potency.

Effects[edit | edit source]

The effects of Delta-8-THC are similar to those of Delta-9-THC but are generally considered to be less intense. Users have reported experiencing a milder high, with less anxiety and paranoia. It is thought to have approximately half the potency of Delta-9-THC. The most common effects include mild euphoria, happiness, uplifting feelings, and relief from some symptoms such as pain, although the scientific evidence supporting these effects is limited.

Medical Use[edit | edit source]

There is growing interest in the medical use of Delta-8-THC due to its psychoactive effects being less intense than those of Delta-9-THC. It has been studied for potential therapeutic effects, including antiemetic (anti-vomiting), anxiolytic (anti-anxiety), appetite-stimulating, analgesic (pain-relieving), and neuroprotective properties. However, research is still in the early stages, and more studies are needed to fully understand its efficacy and safety as a treatment.

Legal Status[edit | edit source]

The legal status of Delta-8-THC varies by jurisdiction. In some countries and states where cannabis and Delta-9-THC are controlled substances, Delta-8-THC may also be regulated under the same laws. However, because it can be synthesized from CBD derived from hemp, which is legal in many places, there is some ambiguity about its legal status in those areas. Consumers should check their local laws before purchasing or using Delta-8-THC products.

Production[edit | edit source]

Delta-8-THC is present in cannabis plants in very low concentrations, making natural extraction not always feasible or cost-effective. As a result, most commercially available Delta-8-THC is synthesized from CBD extracted from legally grown hemp. This process involves converting CBD into Delta-8-THC through a chemical reaction, typically using acids.

Safety and Side Effects[edit | edit source]

As with any cannabinoid, the use of Delta-8-THC can come with side effects, especially when taken in high doses. These can include dry mouth, red eyes, getting the "munchies," short-term memory impairment, paranoia, and anxiety. It is important for users to start with a low dose to assess tolerance and avoid operating heavy machinery or driving while under the influence.

Conclusion[edit | edit source]

Delta-8-THC offers an alternative to those seeking the therapeutic and recreational benefits of cannabinoids with a less intense psychoactive experience than Delta-9-THC. However, due to its legal ambiguity and the need for more research on its effects and safety, consumers should proceed with caution.


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Contributors: Prab R. Tumpati, MD