Demecarium bromide

Demecarium bromide is a pharmacological agent used primarily in the treatment of glaucoma. It belongs to the class of medications known as cholinergic agonists, which work by increasing the outflow of aqueous humor from the eye, thereby reducing intraocular pressure.

Pharmacology

Demecarium bromide is a cholinesterase inhibitor, which means it prevents the breakdown of acetylcholine, a neurotransmitter that transmits signals in the nervous system. By inhibiting the enzyme that breaks down acetylcholine, demecarium bromide increases the amount of acetylcholine available to stimulate the muscarinic receptors in the eye. This stimulation causes the ciliary muscle to contract, which opens the trabecular meshwork and allows the aqueous humor to drain out of the eye.

Clinical Use

Demecarium bromide is used in the treatment of glaucoma, a condition characterized by increased intraocular pressure that can lead to damage to the optic nerve and loss of vision. It is typically used when other treatments have not been effective. Demecarium bromide is administered as eye drops.

Side Effects

Like all medications, demecarium bromide can cause side effects. These may include eye irritation, blurred vision, and changes in vision. In rare cases, systemic side effects such as abdominal cramps, diarrhea, and excessive salivation may occur.

See Also

• Glaucoma
• Cholinergic agonists
• Cholinesterase inhibitors
• Acetylcholine
• Muscarinic receptors
• Ciliary muscle
• Trabecular meshwork
• Optic nerve