Dihydroergoline

Dihydroergoline is a chemical compound that belongs to the ergoline family. It is a semi-synthetic alkaloid derived from ergot, a fungus that grows on rye and other grains. Dihydroergoline is used as a starting point in the synthesis of a variety of therapeutic drugs, particularly those used in the treatment of Parkinson's disease and migraine.

Chemistry[edit | edit source]

Dihydroergoline is a tetracyclic compound that consists of a double-ring system with an additional two rings attached. The structure of dihydroergoline is similar to that of other ergoline derivatives, with the main difference being the presence of two additional hydrogen atoms, hence the prefix "dihydro".

Pharmacology[edit | edit source]

Dihydroergoline derivatives have a wide range of pharmacological activities. They are primarily known for their effects on the central nervous system, where they act as dopamine agonists. This makes them useful in the treatment of conditions such as Parkinson's disease, where there is a deficiency of dopamine in the brain. Some dihydroergoline derivatives are also used in the treatment of migraines, due to their ability to constrict blood vessels in the brain.

Therapeutic Use[edit | edit source]

The most well-known dihydroergoline derivative is bromocriptine, which is used in the treatment of Parkinson's disease, hyperprolactinemia, and acromegaly. Another derivative, dihydroergotamine, is used in the treatment of migraines. These drugs are typically administered orally, but can also be given intravenously in certain situations.

Safety and Side Effects[edit | edit source]

Like all drugs, dihydroergoline derivatives can have side effects. These can include nausea, vomiting, and dizziness. In rare cases, they can cause more serious side effects such as hallucinations, psychosis, and heart problems. Therefore, they should be used under the supervision of a healthcare professional.