Dimercaptosuccinic acid

Dimercaptosuccinic acid (DMSA), also known as succimer, is a medication used to treat lead, mercury, and arsenic poisoning. It is less commonly used for other types of metal poisoning. It is taken by mouth.

Etymology[edit | edit source]

The term "Dimercaptosuccinic acid" is derived from its chemical structure. "Di" means two, "mercapto" refers to the presence of sulfur, and "succinic acid" is a type of dicarboxylic acid. Succimer is a contraction of the full chemical name.

Medical uses[edit | edit source]

DMSA is primarily used to treat lead poisoning, mercury poisoning, and arsenic poisoning. It works by binding to the metals in the body, which are then excreted in the urine. It is less commonly used for other types of metal poisoning.

Side effects[edit | edit source]

Common side effects include nausea, vomiting, and diarrhea. Serious side effects may include allergic reactions, liver problems, and low white blood cell levels. It is unclear if use during pregnancy is safe for the baby.

Pharmacology[edit | edit source]

DMSA is a water-soluble, non-toxic, orally administered, metal chelator which has been in use as an antidote to heavy metal toxicity since the 1950s. It works by binding to metals in the body, which are then excreted in the urine.

History[edit | edit source]

DMSA was first synthesized in the 1950s as a possible treatment for radiation sickness, but it was not until the 1970s that its effectiveness in treating lead poisoning was recognized.

See also[edit | edit source]

Dimercaptosuccinic acid Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.