Pyrophosphatase

Pyrophosphatase is an enzyme that catalyzes the hydrolysis of pyrophosphate to inorganic phosphate. This action serves to provide a thermodynamic pull for many biosynthetic reactions. Pyrophosphatases are categorized into two families based on their dependence on metal ions: soluble inorganic pyrophosphatases and membrane-bound proton-pumping pyrophosphatases.

Function

Pyrophosphatases are essential for many cellular processes, including DNA replication, protein synthesis, and lipid metabolism. They function by hydrolyzing pyrophosphate, a byproduct of many biosynthetic reactions, into inorganic phosphate. This reaction is highly exergonic, and thus provides a thermodynamic pull that drives these biosynthetic reactions forward.

Types

There are two main types of pyrophosphatases: soluble inorganic pyrophosphatases and membrane-bound proton-pumping pyrophosphatases.

Soluble Inorganic Pyrophosphatases

Soluble inorganic pyrophosphatases are dependent on metal ions, such as magnesium, for their activity. They are found in a wide variety of organisms, from bacteria to humans.

Membrane-Bound Proton-Pumping Pyrophosphatases

Membrane-bound proton-pumping pyrophosphatases are also dependent on metal ions, but in addition, they are capable of pumping protons across membranes. This ability allows them to generate a proton gradient, which can be used to drive ATP synthesis.

Clinical Significance

Alterations in pyrophosphatase activity have been implicated in a number of diseases, including osteoporosis, cancer, and certain genetic disorders. For example, increased pyrophosphatase activity has been observed in osteoporotic bone, suggesting a role for this enzyme in bone resorption.

See Also

• Enzyme
• Pyrophosphate
• Osteoporosis
• Cancer
• Genetic disorders

Pyrophosphatase Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski