Double minute chromosome
Double minute chromosome - an extrachromosomal circular dna located in the nucleus that is relatively small in size and contains chromatin but lacks a centromere and telomeres. These circular dnas are found in tumor cells and are able to replicate during cell division during chromosome replication. They often contain extra copies of oncogenes and/or genes involved in drug resistance and lack transcription regulatory elements. Unregulated expression of genes present in these structures may play a role in tumor growth and tumor cell survival.
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