Ethanolamine oleate

From WikiMD's Wellness Encyclopedia

Ethanolamine Oleate is a sclerosing agent used in the treatment of esophageal varices. It is a type of ethanolamine salt of oleic acid and is often used in endoscopic sclerotherapy.

Chemical Structure[edit | edit source]

Ethanolamine Oleate is a long-chain fatty acid ester of ethanolamine. The oleate component is derived from oleic acid, a monounsaturated omega-9 fatty acid found in various animal and vegetable sources. The ethanolamine component is a primary amine and primary alcohol.

Pharmacology[edit | edit source]

Ethanolamine Oleate works by causing inflammation and fibrosis within the varices, leading to their obliteration. It is directly injected into the varices during an endoscopic procedure. The drug has a dual action: the ethanolamine causes sclerosis of the veins, while the oleate component induces thrombosis.

Clinical Use[edit | edit source]

Ethanolamine Oleate is primarily used in the treatment of esophageal varices, which are enlarged veins in the esophagus that can rupture and bleed. This condition is often associated with liver cirrhosis. The drug is also used in the treatment of gastric varices and hemorrhoids.

Side Effects[edit | edit source]

Common side effects of Ethanolamine Oleate include chest pain, fever, and difficulty swallowing. More serious side effects can include severe allergic reactions, blood clots, and perforation of the esophagus.

Contraindications[edit | edit source]

Ethanolamine Oleate should not be used in patients with known hypersensitivity to the drug. It is also contraindicated in patients with severe liver disease, as it can increase the risk of bleeding.

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