Etidronate disodium

Etidronate Disodium is a type of bisphosphonate medication that is primarily used in the treatment of Paget's disease, osteoporosis, and hypercalcemia. It is also known by its brand names, Didronel and EHDP.

Pharmacology

Etidronate Disodium works by inhibiting the osteoclast-mediated bone resorption, which in turn helps to regulate the body's calcium levels. It is a non-nitrogenous bisphosphonate and does not undergo metabolism within the body.

Medical Uses

Etidronate Disodium is used in the treatment of several bone-related conditions. These include:

• Paget's disease: This is a chronic bone disorder that can result in enlarged and misshapen bones. Etidronate Disodium can help to regulate bone growth and reduce pain and other symptoms.
• Osteoporosis: This is a condition that weakens bones, making them fragile and more likely to break. Etidronate Disodium can help to strengthen the bones and reduce the risk of fractures.
• Hypercalcemia: This is a condition characterized by an abnormally high level of calcium in the blood. Etidronate Disodium can help to lower calcium levels.

Side Effects

Like all medications, Etidronate Disodium can cause side effects. These may include gastrointestinal issues such as nausea and diarrhea, as well as bone, joint, or muscle pain. In rare cases, it can cause a serious condition known as osteonecrosis of the jaw.

See Also

• Bisphosphonate
• Osteoporosis
• Paget's disease
• Hypercalcemia