Fc region

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(Redirected from Fc receptor)

Fc Region (Fragment Crystallizable Region)[edit | edit source]

Antibody Chains
Antibody Chains

Fc

The Fc region, short for Fragment Crystallizable region, is a critical component of an antibody's structure. It refers to the tail region of an antibody that interacts with cell surface receptors and other proteins of the immune system.

Diagram of an antibody showing the Fc region

Structure and Location[edit | edit source]

  • The Fc region is located at the base of the Y-shaped antibody molecule.
  • It is composed of constant regions of the heavy chains of the antibody.

Function and Role[edit | edit source]

  • The Fc region is crucial for the antibody's effector functions, such as recruiting other components of the immune system to destroy pathogens.
  • It binds to Fc receptors on the surface of immune cells, triggering immune responses like phagocytosis or antibody-dependent cellular cytotoxicity.

Types of Fc Regions[edit | edit source]

  • Different classes of antibodies (IgG, IgM, IgA, IgE, and IgD) have distinct Fc regions, determining their specific roles and functions in the immune response.

Importance in Therapeutics[edit | edit source]

  • The Fc region is the target for engineering therapeutic antibodies, as modifications to this region can alter the antibody's stability, half-life, and effector functions.
  • It is also involved in antibody-dependent enhancement, a phenomenon where antibodies facilitate viral entry into host cells.

Biotechnological Applications[edit | edit source]

  • In biotechnology, the Fc region is utilized to create fusion proteins for various therapeutic and diagnostic purposes.

See Also[edit | edit source]

External Links[edit | edit source]

References[edit | edit source]


Also see[edit | edit source]

Fc region Resources

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