Friedel–Crafts reaction
(Redirected from Friedel-Crafts alkylation)
Friedel–Crafts Reaction[edit | edit source]
The Friedel–Crafts reaction is a set of reactions developed by Charles Friedel and James Crafts in 1877 to attach substituents to an aromatic ring. These reactions are of two main types: Friedel–Crafts alkylation and Friedel–Crafts acylation.
Friedel–Crafts Alkylation[edit | edit source]
The Friedel–Crafts alkylation involves the alkylation of an aromatic ring with an alkyl halide using a strong Lewis acid catalyst such as aluminum chloride (AlCl₃). This reaction is used to introduce an alkyl group into an aromatic compound.
Mechanism[edit | edit source]
The mechanism of the Friedel–Crafts alkylation involves the formation of a carbocation intermediate. The Lewis acid catalyst helps to generate the carbocation from the alkyl halide, which then attacks the aromatic ring to form the alkylated product.
Limitations[edit | edit source]
Friedel–Crafts alkylation has several limitations, including carbocation rearrangement, polyalkylation, and the deactivation of the aromatic ring by electron-withdrawing groups.
Friedel–Crafts Acylation[edit | edit source]
The Friedel–Crafts acylation involves the acylation of an aromatic ring with an acyl chloride or acid anhydride in the presence of a Lewis acid catalyst. This reaction introduces an acyl group into the aromatic compound.
Mechanism[edit | edit source]
The mechanism of Friedel–Crafts acylation involves the formation of an acylium ion, which is a more stable electrophile than a carbocation. The acylium ion attacks the aromatic ring to form the acylated product.
Advantages[edit | edit source]
Friedel–Crafts acylation does not suffer from polyacylation because the acyl group is electron-withdrawing, which deactivates the aromatic ring towards further electrophilic substitution.
Applications[edit | edit source]
Friedel–Crafts reactions are widely used in the synthesis of aromatic ketones, alkylbenzenes, and other aromatic compounds. They are important in the production of pharmaceuticals, fragrances, and polymers.
Related Reactions[edit | edit source]
Friedel–Crafts reactions are related to other electrophilic aromatic substitution reactions such as nitration, sulfonation, and halogenation.
Related Pages[edit | edit source]
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