Haemosiderin

Haemosiderin is a form of iron storage complex found in the body. It is an insoluble form of iron, unlike its soluble counterpart, ferritin. Haemosiderin is found in situations where iron levels exceed the storage capacity of ferritin, such as in certain types of anemia or iron overload disorders.

Structure and Function

Haemosiderin is composed of denatured protein and iron. It is typically found within cells, particularly those of the mononuclear phagocyte system. The iron within haemosiderin is not readily available for use by the body, making it a less efficient form of iron storage than ferritin.

Clinical Significance

Excessive accumulation of haemosiderin can occur in various conditions, including hemochromatosis, thalassemia, and sickle cell disease. This can lead to haemosiderosis, a condition characterized by iron overload and potential damage to organs such as the liver, heart, and pancreas.

Haemosiderin can also be seen in certain types of bleeding disorders or conditions where there is frequent blood loss. In these situations, the body breaks down red blood cells and stores the iron within haemosiderin. This can be seen in conditions such as hemorrhagic stroke or menorrhagia.

Diagnosis

The presence of haemosiderin can be detected through various methods. Biopsy of affected tissues can reveal haemosiderin deposits. Additionally, certain imaging techniques, such as MRI, can detect haemosiderin due to its magnetic properties.

Treatment

Treatment of conditions involving haemosiderin accumulation typically involves addressing the underlying cause. This may include iron chelation therapy for conditions involving iron overload, or management of bleeding disorders.

See Also

• Iron
• Ferritin
• Hemochromatosis
• Thalassemia
• Sickle cell disease
• Haemosiderosis
• Hemorrhagic stroke
• Menorrhagia

Haemosiderin Resources
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