IL-11
IL-11 is a protein that in humans is encoded by the IL11 gene. IL-11 is a member of the interleukin family, a group of cytokines that are important in cell-to-cell communication in immune responses and during hematopoiesis.
Function[edit | edit source]
IL-11 is produced by stromal cells in the bone marrow and thymus. It functions in many hematopoietic processes, including the stimulation of megakaryocyte maturation and platelet production. IL-11 also has non-hematopoietic functions, such as playing a role in embryo implantation and the function of the gastrointestinal tract.
Clinical significance[edit | edit source]
IL-11 has been used therapeutically in the treatment of thrombocytopenia following chemotherapy for cancer. It is also being investigated for its potential to treat inflammatory diseases such as rheumatoid arthritis and Crohn's disease.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- IL-11 at WikiMD
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Contributors: Prab R. Tumpati, MD
