Megakaryocyte
Megakaryocyte is a large bone marrow cell with a lobulated nucleus responsible for the production of blood thrombocytes (platelets), which are necessary for normal blood clotting. Megakaryocytes usually account for 1 out of 10,000 bone marrow cells but can increase in number nearly 10-fold during the process of thrombopoiesis. They are derived from hematopoietic stem cells in the bone marrow.
Structure[edit | edit source]
Megakaryocytes are 10 to 15 times larger than a typical red blood cell. They have a large, lobulated nucleus, violet granules in their cytoplasm, and demarcation membranes which outline platelet territories.
Function[edit | edit source]
The main function of the megakaryocyte is to produce platelets. This process is regulated by the hormone thrombopoietin. Megakaryocytes also contribute to homeostasis by producing a variety of substances that can promote inflammation and wound healing.
Clinical significance[edit | edit source]
Abnormalities in the number or function of megakaryocytes can lead to a variety of diseases. For example, a decrease in the number of megakaryocytes can lead to thrombocytopenia, a condition characterized by low platelet count. Conversely, an increase in the number of megakaryocytes can lead to thrombocytosis, a condition characterized by a high platelet count.
See also[edit | edit source]
Megakaryocyte Resources | ||
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