Immune reaction
Immune evasion is a strategy used by pathogens and tumors to avoid detection and destruction by the immune system. This strategy is crucial for the survival and proliferation of these harmful entities within the host organism.
Mechanisms of Immune Evasion[edit | edit source]
There are several mechanisms through which pathogens and tumors evade the immune system. These include antigenic variation, immune suppression, and immune avoidance.
Antigenic Variation[edit | edit source]
Antigenic variation is a strategy used by many pathogens to avoid recognition by the immune system. This involves changing the antigens on the surface of the pathogen, which are the targets of the immune response. By constantly changing these antigens, the pathogen can stay one step ahead of the immune system.
Immune Suppression[edit | edit source]
Some pathogens and tumors can suppress the immune response directly. This can be achieved by producing immunosuppressive substances that inhibit the function of immune cells, or by inducing the production of regulatory immune cells that suppress the immune response.
Immune Avoidance[edit | edit source]
Immune avoidance involves hiding from the immune system. This can be achieved by residing in immune-privileged sites where immune cells cannot reach, or by downregulating the expression of antigens on the surface of the pathogen or tumor.
Consequences of Immune Evasion[edit | edit source]
The ability of pathogens and tumors to evade the immune system has significant implications for disease progression and treatment. Immune evasion can lead to chronic infections, cancer progression, and resistance to immunotherapy.
Overcoming Immune Evasion[edit | edit source]
Research is ongoing to develop strategies to overcome immune evasion. These include the development of vaccines that can induce a broad and durable immune response, and immunotherapies that can enhance the immune response or counteract the immunosuppressive strategies of pathogens and tumors.
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Contributors: Prab R. Tumpati, MD
