Interleukin-11
Interleukin-11 (IL-11) is a protein that in humans is encoded by the IL11 gene. IL-11 is a cytokine that was first identified as a transcription factor produced by bone marrow stromal cells that could stimulate the proliferation of cells within the bone marrow.
Function[edit | edit source]
IL-11 is a member of a family of human growth factors, and is involved in several cellular functions such as hematopoiesis and osteogenesis. It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, and induces megakaryocyte maturation resulting in increased platelet production.
Clinical significance[edit | edit source]
IL-11 has been used therapeutically in the treatment of thrombocytopenia following chemotherapy for cancer patients. It is also being investigated for its potential to stimulate the immune system in conditions such as inflammatory bowel disease and rheumatoid arthritis.
See also[edit | edit source]
- Interleukin
- Cytokine
- Hematopoiesis
- Osteogenesis
- Thrombocytopenia
- Inflammatory bowel disease
- Rheumatoid arthritis
References[edit | edit source]
External links[edit | edit source]
- Interleukin-11 at WikiMD
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Contributors: Prab R. Tumpati, MD
