Interleukin-11

Interleukin-11 (IL-11) is a protein that in humans is encoded by the IL11 gene. IL-11 is a cytokine that was first identified as a transcription factor produced by bone marrow stromal cells that could stimulate the proliferation of cells within the bone marrow.

Function

IL-11 is a member of a family of human growth factors, and is involved in several cellular functions such as hematopoiesis and osteogenesis. It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, and induces megakaryocyte maturation resulting in increased platelet production.

Clinical significance

IL-11 has been used therapeutically in the treatment of thrombocytopenia following chemotherapy for cancer patients. It is also being investigated for its potential to stimulate the immune system in conditions such as inflammatory bowel disease and rheumatoid arthritis.

See also

• Interleukin
• Cytokine
• Hematopoiesis
• Osteogenesis
• Thrombocytopenia
• Inflammatory bowel disease
• Rheumatoid arthritis

External links

• Interleukin-11 at WikiMD

Interleukin-11 Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski