Interleukin 17F
Interleukin 17F (IL-17F) is a protein that in humans is encoded by the IL17F gene. It is a member of the interleukin 17 family of cytokines, which are signaling molecules that play a crucial role in the body's immune response.
Function[edit]
IL-17F is produced by T cells and is involved in several immune responses. It stimulates the production of other cytokines such as interleukin 6, interleukin 8, and granulocyte-macrophage colony-stimulating factor, as well as prostaglandins and nitric oxide. IL-17F can also regulate cartilage matrix turnover and inhibit the formation of endothelial tubes.
Clinical significance[edit]
Alterations in the function of IL-17F have been associated with several diseases. For example, it has been implicated in the pathogenesis of rheumatoid arthritis, asthma, and psoriasis. In addition, mutations in the IL17F gene have been linked to susceptibility to chronic mucocutaneous candidiasis.
References[edit]
External links[edit]
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