Granulocyte-macrophage colony-stimulating factor

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a protein that in humans is encoded by the CSF2 gene. GM-CSF is a cytokine that functions as a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes.

Function

GM-CSF is secreted by a number of different cell types including T cells, macrophages, mast cells, natural killer cells, endothelial cells and fibroblasts in response to cytokine or antigen stimulation. It is called a colony-stimulating factor because of its ability to stimulate the growth of cells in colonies in a laboratory setting.

Clinical significance

GM-CSF is used therapeutically in the treatment of neutropenia, a condition characterized by low levels of neutrophils. It is also used in combination with other drugs in the treatment of certain types of cancer.

See also

• Colony-stimulating factor
• Granulocyte colony-stimulating factor
• Macrophage colony-stimulating factor

External links

• Granulocyte-macrophage colony-stimulating factor at WikiMD

Granulocyte-macrophage colony-stimulating factor Resources
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