IL1F5

IL1F5 is a member of the interleukin-1 cytokine family. This cytokine is produced by activated macrophages and is a key player in the regulation of immune responses and inflammation.

Function

IL1F5, also known as Interleukin-36 receptor antagonist or IL-36Ra, is a protein that in humans is encoded by the IL1F5 gene. It is involved in various immune responses, inflammatory processes, and hematopoiesis. This protein is primarily produced by macrophages, a type of white blood cell that engulfs and digests cellular debris, foreign substances, microbes, and cancer cells in a process called phagocytosis.

Structure

The IL1F5 protein is a member of the interleukin-1 cytokine family. This family consists of eleven members, which all play central roles in the regulation of immune and inflammatory responses to infections or sterile insults. IL1F5 shares a similar structure with other members of the interleukin-1 family, including a beta trefoil fold and a core of beta-sheets.

Clinical Significance

Mutations in the IL1F5 gene have been associated with various diseases, including psoriasis, a chronic skin condition, and generalized pustular psoriasis, a severe form of psoriasis that is characterized by small, pus-filled blisters. Studies have shown that IL1F5 plays a crucial role in the pathogenesis of these diseases.

See Also

• Interleukin 1
• Macrophage
• Phagocytosis
• Psoriasis
• Generalized pustular psoriasis

References

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