Interleukin 36 receptor antagonist

Interleukin 36 receptor antagonist (IL-36Ra) is a protein that in humans is encoded by the IL36RN gene. It is a member of the interleukin family, a group of cytokines that play a crucial role in the immune system. IL-36Ra is specifically an antagonist of the interleukin 36 receptor, meaning it blocks the action of interleukin 36.

Function

IL-36Ra is part of the interleukin-1 cytokine family. This cytokine can inhibit the activity of interleukin-36 (IL-36) when bound to the interleukin 1 receptor-like 2 (IL1RL2/IL-1Rrp2). The inhibition of IL-36 activity leads to a reduction in the production of pro-inflammatory cytokines and chemokines, thus playing an important role in immune responses and inflammation.

Clinical significance

Mutations in the IL36RN gene are associated with a group of rare autoinflammatory diseases known as deficiency of the interleukin-36-receptor antagonist (DITRA). These diseases are characterized by recurrent skin pustules and fever, and can also involve other organs.

Research

Research into IL-36Ra is ongoing, with studies investigating its role in various diseases, including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Understanding the function of IL-36Ra and its receptor could potentially lead to new treatments for these and other inflammatory diseases.

See also

• Interleukin 36
• Interleukin 1 receptor-like 2
• Deficiency of the interleukin-36-receptor antagonist