CXCL11

CXCL11 is a small cytokine belonging to the CXC chemokine family that is also known as Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in prostate, kidney and ovary.

Function

CXCL11 attracts activated T cells. It is chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. CXCL11 induces calcium release in activated T-cells and binds to CXCR3. It interacts with glycosaminoglycans (GAGs).

Clinical significance

CXCL11 has been associated with several diseases, including cancer, HIV, and autoimmune diseases. It is also involved in inflammatory responses and immune responses.

See also

• CXC chemokine
• Chemokine
• Cytokine
• Interferon