Interleukin 20
Interleukin 20 (IL-20) is a protein that in humans is encoded by the IL20 gene. It is a member of the interleukin family, a group of signaling molecules that are involved in the immune system's response to disease and injury.
Function[edit | edit source]
IL-20 is a cytokine that is involved in inflammation and immune responses. It is produced by keratinocytes and acts on epithelial cells, keratinocytes, and fibroblasts to stimulate cell proliferation and differentiation. This cytokine can also induce angiogenesis and the production of a variety of inflammatory chemokines.
Clinical significance[edit | edit source]
IL-20 has been implicated in a variety of diseases, including psoriasis, rheumatoid arthritis, and atherosclerosis. It is thought to play a role in the inflammation and tissue damage associated with these conditions.
Interactions[edit | edit source]
IL-20 interacts with two receptors, IL-20R1 and IL-20R2. These receptors are expressed on the surface of cells and bind to IL-20, triggering a series of intracellular events that lead to the biological effects of this cytokine.
References[edit | edit source]
External links[edit | edit source]
- IL20 Gene - NCBI
- Interleukin-20 - UniProt
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Contributors: Prab R. Tumpati, MD
