CCL21
CCL21 is a small cytokine belonging to the CC chemokine family that is also known as 6Ckine (because it has six conserved cysteine residues), exodus-2, and secondary lymphoid-tissue chemokine (SLC). The chemokine CCL21 is involved in the function of the immune system, specifically in the migration of leukocytes in secondary lymphoid organs.
Structure[edit | edit source]
CCL21 is a small protein molecule that is part of the CC chemokine family. It is characterized by having six conserved cysteine residues, which is why it is also known as 6Ckine. The structure of CCL21 is important for its function in the immune system.
Function[edit | edit source]
CCL21 plays a crucial role in the immune system. It is involved in the migration of leukocytes in secondary lymphoid organs. This chemokine attracts dendritic cells, T cells, and B cells by interacting with a cell surface chemokine receptor known as CCR7.
Clinical significance[edit | edit source]
CCL21 has been implicated in various diseases and conditions. It is involved in the pathogenesis of inflammatory and autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. It is also involved in the progression of certain types of cancer, including lung cancer and melanoma.
See also[edit | edit source]
- Chemokine
- Cytokine
- Leukocyte
- Lymphoid organs
- Dendritic cells
- T cells
- B cells
- CCR7
- Rheumatoid arthritis
- Multiple sclerosis
- Lung cancer
- Melanoma
| CCL21 Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
