CXCL14

CXCL14 (C-X-C motif chemokine ligand 14) is a small cytokine belonging to the CXC chemokine family that is also known as breast and kidney-expressed chemokine (BRAK). CXCL14 is secreted by monocytes, macrophages and dendritic cells, and has functions in immune response, tumor suppression, and cell migration.

Structure

CXCL14 is a small protein of 98 amino acids, it is characterized by the presence of four conserved cysteine residues found in CXC chemokines. The first two cysteine residues are separated by one amino acid, represented in this name with an "X".

Function

CXCL14 is a chemoattractant for monocytes and dendritic cells. It is also known to suppress the growth of certain types of tumors, particularly those of the breast and kidney. This is thought to occur through the recruitment of natural killer cells and dendritic cells to the tumor site.

Clinical significance

Due to its role in tumor suppression, CXCL14 has potential as a therapeutic target in cancer treatment. Additionally, its role in immune response suggests it may have applications in treating inflammatory and autoimmune diseases.

See also

• Chemokine
• Cytokine
• Monocyte
• Dendritic cell
• Natural killer cell