Common gamma chain
Common gamma chain (also known as γc or CD132) is a type of protein that is encoded by the IL2RG gene in humans. It is a component of multiple cytokine receptor systems, including those of interleukin 2, interleukin 4, interleukin 7, interleukin 9, interleukin 15, and interleukin 21.
Function[edit | edit source]
The common gamma chain is an important signaling component of many immune system receptors and plays a crucial role in regulating immune response. It is involved in the development and function of T cells, B cells, NK cells, and dendritic cells.
Clinical significance[edit | edit source]
Mutations in the IL2RG gene that encodes the common gamma chain can lead to X-linked severe combined immunodeficiency (X-SCID), a rare and potentially fatal disease. X-SCID is characterized by a lack of functional T cells and NK cells, and non-functional B cells, leading to severe immune deficiency.
Research[edit | edit source]
Research into the common gamma chain and its associated cytokine receptors has potential implications for the treatment of various immune disorders, including autoimmune diseases, allergies, and cancer.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
