Common gamma chain

Common gamma chain (also known as γc or CD132) is a type of protein that is encoded by the IL2RG gene in humans. It is a component of multiple cytokine receptor systems, including those of interleukin 2, interleukin 4, interleukin 7, interleukin 9, interleukin 15, and interleukin 21.

Function

The common gamma chain is an important signaling component of many immune system receptors and plays a crucial role in regulating immune response. It is involved in the development and function of T cells, B cells, NK cells, and dendritic cells.

Clinical significance

Mutations in the IL2RG gene that encodes the common gamma chain can lead to X-linked severe combined immunodeficiency (X-SCID), a rare and potentially fatal disease. X-SCID is characterized by a lack of functional T cells and NK cells, and non-functional B cells, leading to severe immune deficiency.

Research

Research into the common gamma chain and its associated cytokine receptors has potential implications for the treatment of various immune disorders, including autoimmune diseases, allergies, and cancer.

See also

• Interleukin receptor
• Cytokine
• X-linked severe combined immunodeficiency