IL-4
IL-4 or Interleukin 4 is a type of interleukin that is a cytokine produced by T cells in response to antigen stimulation. It has many roles in the immune system, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of B cells into plasma cells. It is a key regulator in humoral and adaptive immunity.
Function[edit | edit source]
IL-4 induces B-cell class switching to IgE, and up-regulates MHC class II production. IL-4 decreases the production of Th1 cells, macrophages, IFN-gamma, and dendritic cell IL-12. Overproduction of IL-4 is associated with allergies.
Clinical significance[edit | edit source]
IL-4 has been associated with several diseases including asthma, rheumatoid arthritis, and cancer. It is also involved in the pathogenesis of allergies and autoimmune diseases.
See also[edit | edit source]
- Interleukin
- Cytokine
- T cells
- B cells
- Plasma cell
- Humoral immunity
- Adaptive immunity
- MHC class II
- Th1 cells
- Macrophages
- IFN-gamma
- Dendritic cell
- IL-12
- Allergies
- Asthma
- Rheumatoid arthritis
- Cancer
- Autoimmune diseases
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Contributors: Prab R. Tumpati, MD
