CXCL17

CXCL17 is a small cytokine belonging to the CXC chemokine family. It is also known as Vascular Endothelial Growth Factor (VEGF)-related chemokine, or DMC (Dendritic cell and Monocyte Chemotactic protein). CXCL17 plays a significant role in immunological responses and pathological conditions.

Function

CXCL17 is a potent chemoattractant for monocytes, dendritic cells, and neutrophils. It is involved in the recruitment of immune cells to sites of inflammation and injury. CXCL17 also has antimicrobial properties and can contribute to the innate immune response against bacterial infections.

Expression

CXCL17 is expressed in various tissues, including the lungs, liver, colon, and stomach. Its expression can be upregulated in response to inflammatory stimuli.

Clinical significance

Abnormal levels of CXCL17 have been associated with various diseases, such as cancer, inflammatory bowel disease, and chronic obstructive pulmonary disease. In cancer, high levels of CXCL17 can promote tumor growth and metastasis by attracting tumor-associated macrophages.

Research

Research on CXCL17 is ongoing to further understand its role in health and disease. It is being studied as a potential biomarker for certain diseases and as a target for therapeutic interventions.