Interleukin 33

From WikiMD's Wellnesspedia

Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene. IL-33 is a member of the interleukin family of cytokines that are involved in the immune response.

Function[edit | edit source]

IL-33 is a cytokine that binds to the ST2 receptor (a member of the Toll-like receptor superfamily) and is known to drive production of other cytokines (such as IL-4, IL-5, and IL-13) that induce T-helper cell type 2 (Th2) responses. It is expressed by various cell types, including fibroblasts, mast cells, and dendritic cells, and can be released upon cell death.

Clinical significance[edit | edit source]

IL-33 has been implicated in a variety of diseases, including asthma, rheumatoid arthritis, and cardiovascular disease. It is thought to play a role in the pathogenesis of these diseases by promoting inflammation and tissue damage.

See also[edit | edit source]

References[edit | edit source]


External links[edit | edit source]


Interleukin 33 Resources

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Contributors: Prab R. Tumpati, MD