CXCL10
CXCL10 or C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family that is also known as Interferon gamma-induced protein 10 (IP-10). CXCL10 is secreted by several cell types in response to Interferon gamma. These cell types include monocytes, endothelial cells and fibroblasts.
Function[edit | edit source]
CXCL10 has been attributed with several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3.
Clinical significance[edit | edit source]
CXCL10 and its receptor CXCR3 have been implicated in the pathogenesis of several diseases, including thyroiditis, hepatitis, arthritis, lupus, and atherosclerosis. Elevated levels of CXCL10 are also found in several clinical disorders such as HIV disease, inflammatory bowel disease, graft-versus-host disease, and tuberculosis.
References[edit | edit source]
See also[edit | edit source]
- Chemokine
- Cytokine
- Interferon gamma
- Monocyte
- Endothelial cell
- Fibroblast
- T cell
- NK cell
- Dendritic cell
- Bone marrow
- Angiogenesis
- CXCR3
- Thyroiditis
- Hepatitis
- Arthritis
- Lupus
- Atherosclerosis
- HIV
- Inflammatory bowel disease
- Graft-versus-host disease
- Tuberculosis
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Contributors: Prab R. Tumpati, MD
