IL1F7

IL1F7 is a gene that encodes the interleukin 37 protein in humans. It is part of the Interleukin-1 family of cytokines, which are involved in various immune responses, inflammatory processes, and hematopoiesis.

Function

The IL1F7 gene is expressed in various tissues, including the immune system and the central nervous system. The protein it encodes, interleukin 37 (IL-37), is a member of the interleukin-1 cytokine family. This cytokine can inhibit the activity of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulate a variety of interleukin 1 related immune and inflammatory responses.

Clinical significance

Mutations in the IL1F7 gene have been associated with various diseases, including autoimmune diseases and cancer. For example, increased expression of IL1F7 has been observed in patients with rheumatoid arthritis, suggesting a potential role in the pathogenesis of this disease. In addition, IL1F7 has been implicated in the regulation of tumor growth and metastasis.

See also

• Interleukin 1
• Interleukin-1 family
• Cytokine
• Immune system
• Inflammation