CCL20
CCL20 or Chemokine (C-C motif) ligand 20 is a small cytokine belonging to the CC chemokine family that is also known as liver activation regulated chemokine (LARC), macrophage inflammatory protein-3 (MIP3A), and Exodus-1. CCL20 is thought to play a role in the immune response by attracting leukocytes to the site of inflammation.
Function[edit | edit source]
CCL20 is expressed in the liver, lungs, lymph nodes and peripheral blood leukocytes. It is strongly upregulated by inflammatory signals, and downregulated by the anti-inflammatory cytokine interleukin 10.
CCL20 attracts certain cells of the immune system, including dendritic cells, effector/memory T-cells and B cells. It is thought to play a role in the development of lymphoid tissue by attracting these cells to the site of inflammation.
Clinical significance[edit | edit source]
CCL20 has been implicated in a number of inflammatory and autoimmune diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. It is also thought to play a role in the progression of certain types of cancer, including colorectal cancer and breast cancer.
See also[edit | edit source]
References[edit | edit source]
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