IL17 family

IL17 family is a group of cytokines that play a crucial role in both acute and chronic inflammatory responses. The IL17 family consists of six members, namely IL17A, IL17B, IL17C, IL17D, IL17E (also known as IL25), and IL17F.

Structure and Function[edit | edit source]

The IL17 family members are structurally related proteins that share a conserved cysteine-knot fold. They are secreted as disulfide-linked homodimers, except for IL17A and IL17F, which can form heterodimers. The IL17 family members are produced by a variety of cell types, including T cells, neutrophils, and monocytes.

The IL17 family members bind to their respective receptors and induce the production of other cytokines, chemokines, and antimicrobial peptides. This leads to the recruitment of neutrophils and monocytes to the site of infection or inflammation, thereby contributing to the host defense mechanisms.

Role in Disease[edit | edit source]

Aberrant expression or function of the IL17 family members has been associated with several inflammatory and autoimmune diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. In addition, they have been implicated in the pathogenesis of certain types of cancer, including colorectal cancer and breast cancer.

Therapeutic Potential[edit | edit source]

Given their role in inflammation and disease, the IL17 family members are considered potential therapeutic targets. Several drugs that target IL17A or its receptor are currently in use or under development for the treatment of psoriasis, rheumatoid arthritis, and other inflammatory diseases.