CCL15
CCL15 or Chemokine (C-C motif) ligand 15 is a small cytokine belonging to the CC chemokine family that is also known as Monotactin-1 (Mtn-1). This chemokine is produced as a protein precursor that is cleaved to generate the mature protein. CCL15 is expressed in liver, lung, and small intestine, and is chemotactic for monocytes and lymphocytes.
Structure[edit | edit source]
CCL15 is a small protein with a molecular weight of approximately 8 kDa. It is composed of 74 amino acids and is structurally related to other chemokines in the CC family. The mature protein is generated by proteolytic cleavage of a precursor protein.
Function[edit | edit source]
CCL15 is a chemotactic factor that attracts monocytes and lymphocytes but not neutrophils. This chemokine is also involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. CCL15 is also thought to be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Clinical significance[edit | edit source]
CCL15 has been implicated in a number of diseases, including rheumatoid arthritis, atherosclerosis, and cancer. In rheumatoid arthritis, CCL15 is thought to play a role in the recruitment of inflammatory cells into the joint. In atherosclerosis, CCL15 may be involved in the recruitment of monocytes into the arterial wall. In cancer, CCL15 may play a role in the growth and spread of tumors.
See also[edit | edit source]
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